Role of pre–extubation fentanyl in mastectomy: a randomized, controlled, double–blind study

Background: Both tracheal intubation and extubation are associated with dangerous consequences such as tachycardia, hypertension, myocardial ischemia arrhythmias. The aim was to evaluate pre–extubation two different doses of fentanyl on hemodynamic stabilization delayed recovery in mastectomy.
 Methodology: randomized controlled double–blind study conducted 126 patients aged 16–60 years, receiving chemotherapy before surgery underwent mastectomy for breast cancer. Patients were randomly allocated into 3 equal groups. Before extubation, received 10 ml saline group (C), 1 µg/kg Group–F1: 2 Group–F2. Mean arterial blood pressure (MAP) heart rate (HR) recorded at T1 (after maintenance anesthesia), T2 giving the test drug), T3 (immediately after extubation), T4 (5 min. extubation) T5 (15 min extubation).
 Results: MAP significantly lower groups compared Group–C without significant deference between HR Group–F2 Group–F1 T3, T5. Time prolonged a difference Group–C.
 Conclusions: Pre–extubation blunted cardiovascular responses respiratory depression or recovery. provide more control but delay time fentanyl.
 Key words: Pre–Extubation, Fentanyl, Mastectomy, Hemodynamics, Recovery
 Preregistration: registered Ethical Committee Faculty Medicine, Cairo University, Cairo, Egypt (approval number: 281)
 Citation: Salman A, Zayed NO, Mansour Howaidi R, Foly AG, ElSharkawy MS, Abdelgalil AS. Role mastectomy: randomized, controlled, study. Anaesth. pain intensive care 2021;25(2):143-149. DOI: 10.35975/apic.v25i2.1462.
 Abbreviations: CST=Craniosacral therapy; SMT=Sensorimotor training; NCLBP=Nonspecific chronic low back pain; VAS=Visual analogue scale; ODI=Oswestry disability index, BDI-II=Beck inventory-II, SF-36=Short Form-36; CSF=cerebral spinal fluid; CSS=craniosacral system; PRM=primary movements
 Received: 27 June 2020, Reviewed: 24 July Accepted: 2020